Santee Hotels Address Convenient to Lake Marion. Going fishing or golfing. The Holiday Inn Santee hotel is perfect for both recreational activities. Just off I 95 in Santee SC our hotels location is less than an hour from both Columbia and Charleston two unique cities to visit for a day trip. For those looking for a little relaxation there is plenty to do in Santee. Our hotels guests can enjoy the numerous golf courses that dot this area. Visitors also tend to gravitate towards Lake Marion for the fishing as this area is famous for its striped bass and huge catfish. The beautiful lake is supplemented by the glorious blooming flowers and the clouds of colorful flitting butterflies that you can find at the Edisto Memorial Gardens. Those on business trips also find it very easy to get things done in Santee SC. The hotels proximity to a number of golf courses can provide a peaceful backdrop for intense meetings and business lunches. The 24 hour Business Center and free Internet access are provided to help you make the most of your time and resources. After a day out on the lake or on the golf courses come back and enjoy some comfort food in the hotels restaurant. Let the heated pool and hot tub work for you after a long day of meetings or play. Southern hospitality is not just a slogan for us. It is our guarantee for great friendly service. Make your reservation today to experience our brand of South Carolina charm.