Sanford North Carolina Hotels the Best of Lee County. Visitors to Lee County enjoy exceptional hospitality and amenities when they choose the Holiday Inn Express Hotel and Suites Sanford North Carolina. The hotels experienced staff makes each guest feel at home. When you are traveling for meetings at Coty, Caterpillar, GKN, General Shale, Pfizer and Moen you will appreciate being just off Hwy 421 and the hotels location in Sanford, NC. The convenient Business Center services and free high speed WiFi access make it easy to stay on top of your deadlines, too, and our meeting room offers an alternative venue for your business meetings in and around Sanford, NC. This hotel is perfect for leisure travelers. Whether you are here to visit Central Carolina Community College or interested in the historic Railroad House were close to everything. We are an ideal choice when you are here to see a performance at the Temple Theatre or to attend the Sanford Pottery Festival in the Spring. Golfers love spending the day on the stunning local courses including Tobacco Road Golf Course. What sets us apart from other hotels in Sanford, NC are the extraordinary amenities we offer our guests. From the areas only year round indoor pool to the Evening Welcome Receptions on Monday through Wednesday, we have what you want. The free hot breakfast and a well equipped Fitness Center and rooms that are an oasis of comfort are why we are the preferred choice of smart guests. Join us!